ParkinsonCanadaV1, Main, Exploration, bibRecord, 000A57

Genomic analysis of the causative agents of coccidiosis in domestic chickens.

Identifieur interne : 000A57 ( Main/Exploration ); précédent : 000A56; suivant : 000A58

Genomic analysis of the causative agents of coccidiosis in domestic chickens.

Auteurs : Adam J. Reid [Royaume-Uni] ; Damer P. Blake [Royaume-Uni] ; Hifzur R. Ansari ; Karen Billington [Royaume-Uni] ; Hilary P. Browne [Royaume-Uni] ; Josephine Bryant [Royaume-Uni] ; Matt Dunn [Royaume-Uni] ; Stacy S. Hung [Canada] ; Fumiya Kawahara [Japon] ; Diego Miranda-Saavedra [Royaume-Uni] ; Tareq B. Malas ; Tobias Mourier [Danemark] ; Hardeep Naghra [Royaume-Uni] ; Mridul Nair ; Thomas D. Otto [Royaume-Uni] ; Neil D. Rawlings [Royaume-Uni] ; Pierre Rivailler [États-Unis] ; Alejandro Sanchez-Flores [Mexique] ; Mandy Sanders [Royaume-Uni] ; Chandra Subramaniam [Royaume-Uni] ; Yea-Ling Tay [Malaisie] ; Yong Woo ; Xikun Wu [Royaume-Uni] ; Bart Barrell [Royaume-Uni] ; Paul H. Dear [Royaume-Uni] ; Christian Doerig [Australie] ; Arthur Gruber [Brésil] ; Alasdair C. Ivens [Royaume-Uni] ; John Parkinson [Canada] ; Marie-Adèle Rajandream [Royaume-Uni] ; Martin W. Shirley [Royaume-Uni] ; Kiew-Lian Wan [Malaisie] ; Matthew Berriman [Royaume-Uni] ; Fiona M. Tomley [Royaume-Uni] ; Arnab Pain [Royaume-Uni]

Source :

Genome research [ 1549-5469 ] ; 2014.

RBID : pubmed:25015382

English descriptors

KwdEn :
- Animals, Cell Line, Chickens, Chromosome Mapping, Coccidiosis (parasitology), Coccidiosis (veterinary), Eimeria (classification), Eimeria (genetics), Gene Expression Profiling, Genome, Protozoan, Phylogeny, Poultry Diseases (parasitology), Proteome, Protozoan Proteins (genetics), Synteny.
MESH :
- chemical , genetics : Protozoan Proteins.
- chemical : Proteome.
- classification : Eimeria.
- genetics : Eimeria.
- parasitology : Coccidiosis, Poultry Diseases.
- veterinary : Coccidiosis.
- Animals, Cell Line, Chickens, Chromosome Mapping, Gene Expression Profiling, Genome, Protozoan, Phylogeny, Synteny.

Abstract

Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.

DOI: 10.1101/gr.168955.113
PubMed: 25015382

Affiliations:

Le document en format XML

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<author><name sortKey="Kawahara, Fumiya" sort="Kawahara, Fumiya" uniqKey="Kawahara F" first="Fumiya" last="Kawahara">Fumiya Kawahara</name>
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<author><name sortKey="Miranda Saavedra, Diego" sort="Miranda Saavedra, Diego" uniqKey="Miranda Saavedra D" first="Diego" last="Miranda-Saavedra">Diego Miranda-Saavedra</name>
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<author><name sortKey="Nair, Mridul" sort="Nair, Mridul" uniqKey="Nair M" first="Mridul" last="Nair">Mridul Nair</name>
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<author><name sortKey="Otto, Thomas D" sort="Otto, Thomas D" uniqKey="Otto T" first="Thomas D" last="Otto">Thomas D. Otto</name>
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<author><name sortKey="Rawlings, Neil D" sort="Rawlings, Neil D" uniqKey="Rawlings N" first="Neil D" last="Rawlings">Neil D. Rawlings</name>
<affiliation wicri:level="1"><nlm:affiliation>European Bioinformatics Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Rivailler, Pierre" sort="Rivailler, Pierre" uniqKey="Rivailler P" first="Pierre" last="Rivailler">Pierre Rivailler</name>
<affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333</wicri:regionArea>
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<author><name sortKey="Sanchez Flores, Alejandro" sort="Sanchez Flores, Alejandro" uniqKey="Sanchez Flores A" first="Alejandro" last="Sanchez-Flores">Alejandro Sanchez-Flores</name>
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<author><name sortKey="Sanders, Mandy" sort="Sanders, Mandy" uniqKey="Sanders M" first="Mandy" last="Sanders">Mandy Sanders</name>
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<author><name sortKey="Subramaniam, Chandra" sort="Subramaniam, Chandra" uniqKey="Subramaniam C" first="Chandra" last="Subramaniam">Chandra Subramaniam</name>
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<author><name sortKey="Tay, Yea Ling" sort="Tay, Yea Ling" uniqKey="Tay Y" first="Yea-Ling" last="Tay">Yea-Ling Tay</name>
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<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor DE, Malaysia; Malaysia Genome Institute, Jalan Bangi, 43000 Kajang, Selangor DE</wicri:regionArea>
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<author><name sortKey="Woo, Yong" sort="Woo, Yong" uniqKey="Woo Y" first="Yong" last="Woo">Yong Woo</name>
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<author><name sortKey="Wu, Xikun" sort="Wu, Xikun" uniqKey="Wu X" first="Xikun" last="Wu">Xikun Wu</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom; Amgen Limited, Uxbridge UB8 1DH</wicri:regionArea>
<wicri:noRegion>Uxbridge UB8 1DH</wicri:noRegion>
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<author><name sortKey="Barrell, Bart" sort="Barrell, Bart" uniqKey="Barrell B" first="Bart" last="Barrell">Bart Barrell</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Dear, Paul H" sort="Dear, Paul H" uniqKey="Dear P" first="Paul H" last="Dear">Paul H. Dear</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Laboratory of Molecular Biology, Cambridge CB2 0QH</wicri:regionArea>
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</author>
<author><name sortKey="Doerig, Christian" sort="Doerig, Christian" uniqKey="Doerig C" first="Christian" last="Doerig">Christian Doerig</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Monash University, Clayton VIC 3800, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology, Monash University, Clayton VIC 3800</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Gruber, Arthur" sort="Gruber, Arthur" uniqKey="Gruber A" first="Arthur" last="Gruber">Arthur Gruber</name>
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<wicri:regionArea>Departament of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000</wicri:regionArea>
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<author><name sortKey="Ivens, Alasdair C" sort="Ivens, Alasdair C" uniqKey="Ivens A" first="Alasdair C" last="Ivens">Alasdair C. Ivens</name>
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<wicri:regionArea>Centre for Immunity, Infection and Evolution, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Program in Molecular Structure and Function, Hospital for Sick Children and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
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</placeName>
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</author>
<author><name sortKey="Rajandream, Marie Adele" sort="Rajandream, Marie Adele" uniqKey="Rajandream M" first="Marie-Adèle" last="Rajandream">Marie-Adèle Rajandream</name>
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</author>
<author><name sortKey="Shirley, Martin W" sort="Shirley, Martin W" uniqKey="Shirley M" first="Martin W" last="Shirley">Martin W. Shirley</name>
<affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Pirbright Laboratory, Pirbright, Surrey GU24 0NF, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Pirbright Institute, Pirbright Laboratory, Pirbright, Surrey GU24 0NF</wicri:regionArea>
<wicri:noRegion>Surrey GU24 0NF</wicri:noRegion>
</affiliation>
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<author><name sortKey="Wan, Kiew Lian" sort="Wan, Kiew Lian" uniqKey="Wan K" first="Kiew-Lian" last="Wan">Kiew-Lian Wan</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor DE, Malaysia; Malaysia Genome Institute, Jalan Bangi, 43000 Kajang, Selangor DE, Malaysia;</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor DE, Malaysia; Malaysia Genome Institute, Jalan Bangi, 43000 Kajang, Selangor DE</wicri:regionArea>
<wicri:noRegion>Selangor DE</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berriman, Matthew" sort="Berriman, Matthew" uniqKey="Berriman M" first="Matthew" last="Berriman">Matthew Berriman</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tomley, Fiona M" sort="Tomley, Fiona M" uniqKey="Tomley F" first="Fiona M" last="Tomley">Fiona M. Tomley</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal Veterinary College, North Mymms, Hertfordshire AL9 7TA, United Kingdom; The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom; ar11@sanger.ac.uk ftomley@rvc.ac.uk arnab.pain@kaust.edu.sa.</nlm:affiliation>
<country wicri:rule="url">Royaume-Uni</country>
<wicri:regionArea>Royal Veterinary College, North Mymms, Hertfordshire AL9 7TA, United Kingdom; The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN</wicri:regionArea>
<wicri:noRegion>Berkshire RG20 7NN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pain, Arnab" sort="Pain, Arnab" uniqKey="Pain A" first="Arnab" last="Pain">Arnab Pain</name>
<affiliation wicri:level="1"><nlm:affiliation>Computational Bioscience Research Center, Biological Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Kingdom of Saudi Arabia; ar11@sanger.ac.uk ftomley@rvc.ac.uk arnab.pain@kaust.edu.sa.</nlm:affiliation>
<country wicri:rule="url">Royaume-Uni</country>
<wicri:regionArea>Computational Bioscience Research Center, Biological Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900</wicri:regionArea>
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</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Genomic analysis of the causative agents of coccidiosis in domestic chickens.</title>
<author><name sortKey="Reid, Adam J" sort="Reid, Adam J" uniqKey="Reid A" first="Adam J" last="Reid">Adam J. Reid</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Blake, Damer P" sort="Blake, Damer P" uniqKey="Blake D" first="Damer P" last="Blake">Damer P. Blake</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal Veterinary College, North Mymms, Hertfordshire AL9 7TA, United Kingdom; The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Veterinary College, North Mymms, Hertfordshire AL9 7TA, United Kingdom; The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN</wicri:regionArea>
<wicri:noRegion>Berkshire RG20 7NN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ansari, Hifzur R" sort="Ansari, Hifzur R" uniqKey="Ansari H" first="Hifzur R" last="Ansari">Hifzur R. Ansari</name>
<affiliation><nlm:affiliation>Computational Bioscience Research Center, Biological Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Kingdom of Saudi Arabia;</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Billington, Karen" sort="Billington, Karen" uniqKey="Billington K" first="Karen" last="Billington">Karen Billington</name>
<affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN</wicri:regionArea>
<wicri:noRegion>Berkshire RG20 7NN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Browne, Hilary P" sort="Browne, Hilary P" uniqKey="Browne H" first="Hilary P" last="Browne">Hilary P. Browne</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bryant, Josephine" sort="Bryant, Josephine" uniqKey="Bryant J" first="Josephine" last="Bryant">Josephine Bryant</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dunn, Matt" sort="Dunn, Matt" uniqKey="Dunn M" first="Matt" last="Dunn">Matt Dunn</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hung, Stacy S" sort="Hung, Stacy S" uniqKey="Hung S" first="Stacy S" last="Hung">Stacy S. Hung</name>
<affiliation wicri:level="4"><nlm:affiliation>Program in Molecular Structure and Function, Hospital for Sick Children and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada;</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Program in Molecular Structure and Function, Hospital for Sick Children and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kawahara, Fumiya" sort="Kawahara, Fumiya" uniqKey="Kawahara F" first="Fumiya" last="Kawahara">Fumiya Kawahara</name>
<affiliation wicri:level="1"><nlm:affiliation>Nippon Institute for Biological Science, Ome, Tokyo 198-0024, Japan;</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Nippon Institute for Biological Science, Ome, Tokyo 198-0024</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Miranda Saavedra, Diego" sort="Miranda Saavedra, Diego" uniqKey="Miranda Saavedra D" first="Diego" last="Miranda-Saavedra">Diego Miranda-Saavedra</name>
<affiliation wicri:level="1"><nlm:affiliation>Fibrosis Laboratories, Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Fibrosis Laboratories, Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne NE2 4HH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malas, Tareq B" sort="Malas, Tareq B" uniqKey="Malas T" first="Tareq B" last="Malas">Tareq B. Malas</name>
<affiliation><nlm:affiliation>Computational Bioscience Research Center, Biological Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Kingdom of Saudi Arabia;</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mourier, Tobias" sort="Mourier, Tobias" uniqKey="Mourier T" first="Tobias" last="Mourier">Tobias Mourier</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmark;</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Naghra, Hardeep" sort="Naghra, Hardeep" uniqKey="Naghra H" first="Hardeep" last="Naghra">Hardeep Naghra</name>
<affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom; School of Life Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom; School of Life Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD</wicri:regionArea>
<orgName type="university">Université de Nottingham</orgName>
<placeName><settlement type="city">Nottingham</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Nottinghamshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nair, Mridul" sort="Nair, Mridul" uniqKey="Nair M" first="Mridul" last="Nair">Mridul Nair</name>
<affiliation><nlm:affiliation>Computational Bioscience Research Center, Biological Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Kingdom of Saudi Arabia;</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Otto, Thomas D" sort="Otto, Thomas D" uniqKey="Otto T" first="Thomas D" last="Otto">Thomas D. Otto</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rawlings, Neil D" sort="Rawlings, Neil D" uniqKey="Rawlings N" first="Neil D" last="Rawlings">Neil D. Rawlings</name>
<affiliation wicri:level="1"><nlm:affiliation>European Bioinformatics Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>European Bioinformatics Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rivailler, Pierre" sort="Rivailler, Pierre" uniqKey="Rivailler P" first="Pierre" last="Rivailler">Pierre Rivailler</name>
<affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333</wicri:regionArea>
<wicri:noRegion>Georgia 30333</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sanchez Flores, Alejandro" sort="Sanchez Flores, Alejandro" uniqKey="Sanchez Flores A" first="Alejandro" last="Sanchez-Flores">Alejandro Sanchez-Flores</name>
<affiliation wicri:level="1"><nlm:affiliation>Unidad Universitaria de Apoyo Bioinformático, Institute of Biotechnology, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62210, Mexico;</nlm:affiliation>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Unidad Universitaria de Apoyo Bioinformático, Institute of Biotechnology, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62210</wicri:regionArea>
<wicri:noRegion>Morelos 62210</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sanders, Mandy" sort="Sanders, Mandy" uniqKey="Sanders M" first="Mandy" last="Sanders">Mandy Sanders</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Subramaniam, Chandra" sort="Subramaniam, Chandra" uniqKey="Subramaniam C" first="Chandra" last="Subramaniam">Chandra Subramaniam</name>
<affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN</wicri:regionArea>
<wicri:noRegion>Berkshire RG20 7NN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tay, Yea Ling" sort="Tay, Yea Ling" uniqKey="Tay Y" first="Yea-Ling" last="Tay">Yea-Ling Tay</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor DE, Malaysia; Malaysia Genome Institute, Jalan Bangi, 43000 Kajang, Selangor DE, Malaysia;</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor DE, Malaysia; Malaysia Genome Institute, Jalan Bangi, 43000 Kajang, Selangor DE</wicri:regionArea>
<wicri:noRegion>Selangor DE</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Woo, Yong" sort="Woo, Yong" uniqKey="Woo Y" first="Yong" last="Woo">Yong Woo</name>
<affiliation><nlm:affiliation>Computational Bioscience Research Center, Biological Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Kingdom of Saudi Arabia;</nlm:affiliation>
<wicri:noCountry code="subField">Kingdom of Saudi Arabia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wu, Xikun" sort="Wu, Xikun" uniqKey="Wu X" first="Xikun" last="Wu">Xikun Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom; Amgen Limited, Uxbridge UB8 1DH, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom; Amgen Limited, Uxbridge UB8 1DH</wicri:regionArea>
<wicri:noRegion>Uxbridge UB8 1DH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barrell, Bart" sort="Barrell, Bart" uniqKey="Barrell B" first="Bart" last="Barrell">Bart Barrell</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dear, Paul H" sort="Dear, Paul H" uniqKey="Dear P" first="Paul H" last="Dear">Paul H. Dear</name>
<affiliation wicri:level="1"><nlm:affiliation>MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Laboratory of Molecular Biology, Cambridge CB2 0QH</wicri:regionArea>
<wicri:noRegion>Cambridge CB2 0QH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Doerig, Christian" sort="Doerig, Christian" uniqKey="Doerig C" first="Christian" last="Doerig">Christian Doerig</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Monash University, Clayton VIC 3800, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology, Monash University, Clayton VIC 3800</wicri:regionArea>
<wicri:noRegion>Clayton VIC 3800</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gruber, Arthur" sort="Gruber, Arthur" uniqKey="Gruber A" first="Arthur" last="Gruber">Arthur Gruber</name>
<affiliation wicri:level="4"><nlm:affiliation>Departament of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil;</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Departament of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000</wicri:regionArea>
<orgName type="university">Université de São Paulo</orgName>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ivens, Alasdair C" sort="Ivens, Alasdair C" uniqKey="Ivens A" first="Alasdair C" last="Ivens">Alasdair C. Ivens</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Immunity, Infection and Evolution, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Immunity, Infection and Evolution, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name>
<affiliation wicri:level="4"><nlm:affiliation>Program in Molecular Structure and Function, Hospital for Sick Children and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada;</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Program in Molecular Structure and Function, Hospital for Sick Children and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rajandream, Marie Adele" sort="Rajandream, Marie Adele" uniqKey="Rajandream M" first="Marie-Adèle" last="Rajandream">Marie-Adèle Rajandream</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shirley, Martin W" sort="Shirley, Martin W" uniqKey="Shirley M" first="Martin W" last="Shirley">Martin W. Shirley</name>
<affiliation wicri:level="1"><nlm:affiliation>The Pirbright Institute, Pirbright Laboratory, Pirbright, Surrey GU24 0NF, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Pirbright Institute, Pirbright Laboratory, Pirbright, Surrey GU24 0NF</wicri:regionArea>
<wicri:noRegion>Surrey GU24 0NF</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wan, Kiew Lian" sort="Wan, Kiew Lian" uniqKey="Wan K" first="Kiew-Lian" last="Wan">Kiew-Lian Wan</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor DE, Malaysia; Malaysia Genome Institute, Jalan Bangi, 43000 Kajang, Selangor DE, Malaysia;</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor DE, Malaysia; Malaysia Genome Institute, Jalan Bangi, 43000 Kajang, Selangor DE</wicri:regionArea>
<wicri:noRegion>Selangor DE</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berriman, Matthew" sort="Berriman, Matthew" uniqKey="Berriman M" first="Matthew" last="Berriman">Matthew Berriman</name>
<affiliation wicri:level="1"><nlm:affiliation>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom;</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA</wicri:regionArea>
<wicri:noRegion>Cambridgeshire CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tomley, Fiona M" sort="Tomley, Fiona M" uniqKey="Tomley F" first="Fiona M" last="Tomley">Fiona M. Tomley</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal Veterinary College, North Mymms, Hertfordshire AL9 7TA, United Kingdom; The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdom; ar11@sanger.ac.uk ftomley@rvc.ac.uk arnab.pain@kaust.edu.sa.</nlm:affiliation>
<country wicri:rule="url">Royaume-Uni</country>
<wicri:regionArea>Royal Veterinary College, North Mymms, Hertfordshire AL9 7TA, United Kingdom; The Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN</wicri:regionArea>
<wicri:noRegion>Berkshire RG20 7NN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pain, Arnab" sort="Pain, Arnab" uniqKey="Pain A" first="Arnab" last="Pain">Arnab Pain</name>
<affiliation wicri:level="1"><nlm:affiliation>Computational Bioscience Research Center, Biological Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900, Kingdom of Saudi Arabia; ar11@sanger.ac.uk ftomley@rvc.ac.uk arnab.pain@kaust.edu.sa.</nlm:affiliation>
<country wicri:rule="url">Royaume-Uni</country>
<wicri:regionArea>Computational Bioscience Research Center, Biological Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Jeddah 23955-6900</wicri:regionArea>
<wicri:noRegion>Jeddah 23955-6900</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Genome research</title>
<idno type="eISSN">1549-5469</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Chickens</term>
<term>Chromosome Mapping</term>
<term>Coccidiosis (parasitology)</term>
<term>Coccidiosis (veterinary)</term>
<term>Eimeria (classification)</term>
<term>Eimeria (genetics)</term>
<term>Gene Expression Profiling</term>
<term>Genome, Protozoan</term>
<term>Phylogeny</term>
<term>Poultry Diseases (parasitology)</term>
<term>Proteome</term>
<term>Protozoan Proteins (genetics)</term>
<term>Synteny</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protozoan Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Proteome</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Eimeria</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Eimeria</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Coccidiosis</term>
<term>Poultry Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coccidiosis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Chickens</term>
<term>Chromosome Mapping</term>
<term>Gene Expression Profiling</term>
<term>Genome, Protozoan</term>
<term>Phylogeny</term>
<term>Synteny</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Brésil</li>
<li>Canada</li>
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<li>Japon</li>
<li>Malaisie</li>
<li>Mexique</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
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<li>Nottingham</li>
<li>São Paulo</li>
<li>Tokyo</li>
<li>Toronto</li>
<li>Édimbourg</li>
</settlement>
<orgName><li>Université d'Édimbourg</li>
<li>Université de Nottingham</li>
<li>Université de São Paulo</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Ansari, Hifzur R" sort="Ansari, Hifzur R" uniqKey="Ansari H" first="Hifzur R" last="Ansari">Hifzur R. Ansari</name>
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<name sortKey="Nair, Mridul" sort="Nair, Mridul" uniqKey="Nair M" first="Mridul" last="Nair">Mridul Nair</name>
<name sortKey="Woo, Yong" sort="Woo, Yong" uniqKey="Woo Y" first="Yong" last="Woo">Yong Woo</name>
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<name sortKey="Bryant, Josephine" sort="Bryant, Josephine" uniqKey="Bryant J" first="Josephine" last="Bryant">Josephine Bryant</name>
<name sortKey="Dear, Paul H" sort="Dear, Paul H" uniqKey="Dear P" first="Paul H" last="Dear">Paul H. Dear</name>
<name sortKey="Dunn, Matt" sort="Dunn, Matt" uniqKey="Dunn M" first="Matt" last="Dunn">Matt Dunn</name>
<name sortKey="Ivens, Alasdair C" sort="Ivens, Alasdair C" uniqKey="Ivens A" first="Alasdair C" last="Ivens">Alasdair C. Ivens</name>
<name sortKey="Miranda Saavedra, Diego" sort="Miranda Saavedra, Diego" uniqKey="Miranda Saavedra D" first="Diego" last="Miranda-Saavedra">Diego Miranda-Saavedra</name>
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<name sortKey="Otto, Thomas D" sort="Otto, Thomas D" uniqKey="Otto T" first="Thomas D" last="Otto">Thomas D. Otto</name>
<name sortKey="Pain, Arnab" sort="Pain, Arnab" uniqKey="Pain A" first="Arnab" last="Pain">Arnab Pain</name>
<name sortKey="Rajandream, Marie Adele" sort="Rajandream, Marie Adele" uniqKey="Rajandream M" first="Marie-Adèle" last="Rajandream">Marie-Adèle Rajandream</name>
<name sortKey="Rawlings, Neil D" sort="Rawlings, Neil D" uniqKey="Rawlings N" first="Neil D" last="Rawlings">Neil D. Rawlings</name>
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<name sortKey="Shirley, Martin W" sort="Shirley, Martin W" uniqKey="Shirley M" first="Martin W" last="Shirley">Martin W. Shirley</name>
<name sortKey="Subramaniam, Chandra" sort="Subramaniam, Chandra" uniqKey="Subramaniam C" first="Chandra" last="Subramaniam">Chandra Subramaniam</name>
<name sortKey="Tomley, Fiona M" sort="Tomley, Fiona M" uniqKey="Tomley F" first="Fiona M" last="Tomley">Fiona M. Tomley</name>
<name sortKey="Wu, Xikun" sort="Wu, Xikun" uniqKey="Wu X" first="Xikun" last="Wu">Xikun Wu</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Hung, Stacy S" sort="Hung, Stacy S" uniqKey="Hung S" first="Stacy S" last="Hung">Stacy S. Hung</name>
</region>
<name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name>
</country>
<country name="Japon"><noRegion><name sortKey="Kawahara, Fumiya" sort="Kawahara, Fumiya" uniqKey="Kawahara F" first="Fumiya" last="Kawahara">Fumiya Kawahara</name>
</noRegion>
</country>
<country name="Danemark"><region name="Hovedstaden"><name sortKey="Mourier, Tobias" sort="Mourier, Tobias" uniqKey="Mourier T" first="Tobias" last="Mourier">Tobias Mourier</name>
</region>
</country>
<country name="États-Unis"><noRegion><name sortKey="Rivailler, Pierre" sort="Rivailler, Pierre" uniqKey="Rivailler P" first="Pierre" last="Rivailler">Pierre Rivailler</name>
</noRegion>
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<country name="Mexique"><noRegion><name sortKey="Sanchez Flores, Alejandro" sort="Sanchez Flores, Alejandro" uniqKey="Sanchez Flores A" first="Alejandro" last="Sanchez-Flores">Alejandro Sanchez-Flores</name>
</noRegion>
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</noRegion>
<name sortKey="Wan, Kiew Lian" sort="Wan, Kiew Lian" uniqKey="Wan K" first="Kiew-Lian" last="Wan">Kiew-Lian Wan</name>
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<country name="Australie"><noRegion><name sortKey="Doerig, Christian" sort="Doerig, Christian" uniqKey="Doerig C" first="Christian" last="Doerig">Christian Doerig</name>
</noRegion>
</country>
<country name="Brésil"><region name="État de São Paulo"><name sortKey="Gruber, Arthur" sort="Gruber, Arthur" uniqKey="Gruber A" first="Arthur" last="Gruber">Arthur Gruber</name>
</region>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Genomic analysis of the causative agents of coccidiosis in domestic chickens.

Genomic analysis of the causative agents of coccidiosis in domestic chickens.

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	La maladie de Parkinson au Canada (serveur d'exploration)
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